by Beyond Lab
A recent extensive study showed that different genetic mutations (personal genomics)of a single gene could result in different drug response.
The most common lung cancer - non-small cell lung cancer - is associated with mutations of a gene called EGFR. Using AstaZeneca’s cancer drug Iressa (gefitinib), this study found that patients' drug-response, to a large degree, depends on the specific mutations. Without going into the details, this study indeed support the potential application of personal genomics in medical practice. Once enough genetic, genomic and clinical information is accumulated, doctors could select treatment that will sure be effective based on patients' genome -- so called personalized medicine.