Friday, April 18, 2008

alcoholism connected to epigenetics

Epigenetics gets real!!!

A group from Chicago published a paper two weeks ago connecting chromatin remodeling (epigenetics) in brain to alcoholism. It is exciting because this is for the first clear evidence, as far as I know, humans' everyday activity could affect epigenetics.

Using laboratory rats as model, they found that acute anti-anxiety effects of alcohol are mediated by reduced histone (H3 and H4) acetylation in the amygdala region of the brain. What's more interesting is that increased anxiety accompanied with withdrawal from alcohol dependence is caused by a further increase in this process (acetylation). Neuropeptide Y, a known protein and mediator of anti-anxiety, is a potential target of the transcriptional regulation associated with this epigenetic mechanism. Inhibition of this process could indeed prevent anxiety. These data could potentially explain a lot of symptoms related to alcoholism and withdrawal anxiety. The clinical significance will have to be proved by further study.

When you drink next time, remind yourself that you are modifying your epigenome!

5 comments:

xanax said...

The anti-anxiety medicine xanax is wholly capable of facilitating your war against anxiety as it is the most widely recognized medication to treat anxiety disorders, especially generalized anxiety disorders and altogether Xanax can treat a whole lot of anxieties related to panic disorders and depression. Before you move on to administer Xanax and treat your anxiety, get hold of Xanax tidbits from the site http://www.pill-care.com

Buy Cialis said...

hello friend excellent topic about alcoholism connected to epigenetics, the alcoholism is a big problems!!! that affect younger

Online Pharmacy said...

Good Morning !!! I would like to have some update about this information alcoholism connected to epigenetics. I wife is an alcoholic person ans I'm very interesting this topic!!!

Tadalafil said...

amazing post about alcoholism connected to epigenetics thanks for sharing!!

niz said...

To start with I would like to congratulate the cradores of this blog, mainly because when I read it I enjoyed it very much. A few years ago I attended a conference called guanacaste costa rica real estate, at that conference had many interesting topics. Perhaps readers may find no relationship between the blog and this conference, but if someday can attend, would realize that there is much to do with this blog.